The Wright Brothers were Zetetists.
"Science theory held us up for years. When we threw out all science, started from experiment and experience, then we invented the airplane." -- The Wright Brothers
In fact, most inventions and pharmaceuticals were created from experiment to experience.
First, I find your source highly unreliable. It doesn't provide any citation for it and just asserts it. It doesn't even say which of the Wright brothers said it.
But notice how that isn't the Zetetictic method as outlined by various sources? (Which matches them not claiming to follow a zetetic method)
They didn't have a question to answer and set out to answer that question by making an experiment.
They were trying to make flying machines.
From how the quote describes it, they set out to experiment to find out how flight works, using science to build a flying machine.
The Zetetictic approach wouldn't be building on those experiences to try to produce a model and understand how flight works.
It would be building a machine, and then seeing if it flies. If it doesn't it answers the question, that can't fly.
Exactly what science do you think they threw out as there were already people building flying machines (with arguable claims to it working due to control issues)?
As for inventions and pharmaceuticals, they can be broken into 2 broad categories, those which are pure fluke where they discover something they didn't mean to by accident, and those which again follow a scientific approach of building upon experience to produce a model.
Pharmaceuticals typically fall into the latter with the former only really being for investigation of natural products.
They analyse the binding site of the drug and understand how it interacts and then typically improve upon the molecular structure to make it more potent and/or selective.
They don't just make a random compound and say hey does this work?
Zeteticism can only be used for answering simple questions like does this screen work, or is this small object flat.
It cannot be used for more complex tasks such as determining the shape of a massive object which you can only see a tiny portion of.
The only people that can be pure Zetetics, relying only upon their own experiences, when it comes to the shape of Earth are Astronauts. Those who have gone far enough up to be able to see enough of Earth to be able to make a simple determine of if it is flat or round rather than developing a model and seeing if it matches.
A key part of science is experimentation. Seeing how well a model matches reality and then tuning the model.